Nutrient status can look normal on labs and still be wrong in the brain. TCN2 is the clean example. Detox rows sit in the same walk-through because they changed what I avoid.
3.33× peripheral neuropathy risk, rising to 6.9× if folate exceeds 800 mg/day. Brain B12 can be low even when blood B12 reads normal.
This is why high-B12 foods land on the protocol table.
Explicit non-responder flag: two-copy carriers generally do not get significant homocysteine reduction with folate.
That is a ledger row, not a slogan.
MUC1 CC, two copies, high impact, 16% prevalence, drives magnesium threonate plus high-magnesium foods. FGFR2 is the companion printed “rare SNP” at 14.6% prevalence.
Both sit in the mineral story, not the amyloid story.
GSTP1 GG, two copies, high impact, 11.1% prevalence: 4.8× and 1.84× cognitive-impairment and glyphosate figures, plus lead-exposure cognitive effects. GSTM1 complete gene deletion, two copies, high, with an additive interaction with the other glutathione genes.
This drives “avoid glyphosates” and “avoid smoke” on the protocol table.
Printed increased size of stroke damage and psychosis notes. Prevalence 11.7%.
Sulforaphane and omega-3s list this row among their drivers. I am not expanding excluded panels around it.
CYP2R1 AG sits in the Vitamin D Benefit panel, but the report prints that one variant is actually a risk for vitamin D deficiency. A variant filed under “benefit” that the report itself argues with is exactly the texture this page should surface.
I did not treat folate as the homocysteine answer. I did treat glyphosate and smoke as avoid items because GSTP1 printed them that way.
Nutrient and detox rows are not SPECT blood flow and not QEEG rhythm. Omitted: any AGREES claim.
How it works is the primer. The library is the index. The other spokes are the payload.
Folate, interferon, and the rest of the negative ledger sit on the next spoke.